IVF success rate in india or In-vitro fertilization success rate has been a boon to those infertile couples dreaming to start a family. IVF is a process where an egg from a female body is combined with her partner sperm outside their body. The outcome of an IVF procedure varies from one couple to another and one clinic to another.
IVF success rate refers to the number of IVF cycles that result in a clinical pregnancy and live births. This definition is pretty simple and clear, but still, it creates a lot of confusion, because some clinics provide the number of live births as their “IVF success rate”, some provide the number of successful embryo implantations, some combine these two numbers. For this reason, it may not be that clear-cut understandable.
The success rate of IVF procedure depends upon varies factors as given below:
- Age of the female partner
- Duration of infertility
- Type of infertility (primary or secondary)
- Cause of infertility
- Quality of the sperm, egg, and embryo
- The endometrial development
- Luteal phase post transfer
With respect to the above-given factors, in India, the success rate of IVF ranges from 30% to 35%. Globally, the average IVF success rate is around 40% in young women. The chance of success rates also increases in women younger than 35 years of age. The success rate of this most commonly used assisted reproductive technology or ART is usually measured on the basis of live birth per embryo transfer. Live birth per embryo transfer is known as Live birth rate.
Nowadays, most of the clinics have adopted a “freeze all” technique, where the embryos generated after ICSI or conventional IVF are frozen and not eggs. With the use of new age reproductive techniques, the IVF success rates in India have increased considerably. Endometrial receptivity analysis (ERA) is one such technique that can be helpful in patients with recurrent implantation failure by studying the endometrium at a molecular level.
In case of advanced maternal age, most of the implantation failures happen due to the chromosomal abnormalities of the embryos, a Pre implantation Genetic Screening (PGS) is highly recommended to increase the chance of implantation.
In certain couples, the conventional IVF treatments may not be of much help. For them, the Intra Cytoplasmic Sperm Injection (ICSI) which is a further classification of IVF could be a ray of hope. It is a laboratory procedure where a single sperm is picked up and injected directly into an egg with a fine glass needle.
A lot of challenges are faced during an IVF treatment; one must undergo these procedures and screening to ensure a greater chance of success.
Potential factors influencing the success rate in delhi & Cost of IVF in Delhi
Each IVF is different and may require a different set of protocols to be followed. A small change in the procedure and inclusion of assistance with advanced IVF techniques can improve one’s possibility of becoming a parent. IVF depends on the following deciding factors that can change the overall cost of implantation. we should discuss about the additonal technology before decide any treatment at IVF centre
- Assisted Hatching: The embryo quality greatly defines the success of implantation. The embryo is well protected by a protective protein shield called Zona pellucida. To successfully implant, the embryo must break its protective sheath. In assisted hatching, the embryologists carefully manipulate these layers of protein under the microscope to help implantation. The charges of this highly specialized procedure are not included in the basic cost.
- Intracytoplasmic sperm injection (ICSI): For male fertility issues like low sperm count or poor sperm quality or less motile sperms, ICSI can help by direct injection of a single sperm into the egg aiding fertilization. However, this procedure comes with an additional cost.
- Preimplantation genetic screening or diagnosis (PGS/PGD): This genetic testing procedure screens the embryos for the presence of any chromosomal anomalies like aneuploids (missing or addition of chromosomes), chromosomal aberrations, translocations, single-gene disorders. For patients with a high risk of hereditary disorders, PGS/PGD can be considered with extra cost inclusions.
- Testicular sperm extraction (TESE): In case of no sperm retrieval or ejaculation issues in men, TESE can be done to extract sperms directly from the sperm-producing organs. This is a minimally invasive surgical procedure that adds to the cost.
- Egg/Sperm donor: Sometimes, donor eggs and donor sperms may be required; treatments involving donor egg or sperm will increase the rates to compensate the costs brought about by donation.
- Embryo donation: The cost of embryo donation is generally less than the overall cost of the IVF procedure. But, checking with your clinic regarding the charges would be ideal.
- Surrogacy: When the embryo transfer is performed on a surrogate mother, then the costs will rise up with additional charges for the care and need of the surrogate mother.
IVF Treatment Options in India
The following fertility treatments are available at indian fertility center
- IUI (intrauterine insemination) and AID (artificial insemination with donor)
- Egg donation (own egg bank)
- Donor sperm (own sperm bank)
- Embryo donation
- Embryo freezing
- Sperm freezing
IVF Success Rates in India and Fertility clinics in New Delhi
Success rates are good, particularly for egg donation. The egg donation clinical pregnancy success rate of 2018 was 97.6% and IVF clinical rate was 86.9%. In 2018, the IVF with own eggs clinical pregnancy success rates were:
- under 35 years old: 78.6%
- 35-40 years old: 66.7%
- over 40 years old: 54.4% (with PGD 76.2%)
Frozen embryo clinical pregnancy rate was 56% and embryo donation clinical pregnancy rate was 67.2%. The clinical pregnancy success rate for the ROPA method was 50.14%. Clinica Tambre submits their results to the Spanish Fertility Society (SEF) for verification. The recent success rates for 2020 will be published as soon as SEF audits them. In 2018, the multiple birth rate was 2.1%. The clinic’s preferred day of transfer is day 5 of the blastocyst stage.
What is the best way to improve IVF rate of success?
The majority of clinics are now using the “freeze all” procedure, where embryos produced using IUI, ICSI, or traditional IVF are frozen instead of eggs. IVF results in India have increased dramatically due to the advancement of reproductive technology. Endometrial Receptivity Analysis (ERA) is a method that analyzes the endometrium on the molecular level. It may help you in cases of persistent implantation failure.
Since the majority of implantation problems are due to abnormalities in the chromosomes of embryos of the advanced stages of maternal age, A Genetic Screening before implantation (PGS) is highly recommended to increase the odds of implantation. If the conventional IVF treatment isn’t helping it is recommended to opt for ICSI. ICSI procedure. IntraCytoplasmic Sperm Injection (ICSI) is a subset of IVF that may be the answer. One sperm is taken up and then inserted directly into the egg using the needle of fine glass in a laboratory.
IVF SUCCESS RATE BY NUMBER OF EMBRYOS
There are plenty of factors affecting the success rate of IVF (in-vitro fertilization) treatment but one of the most important factors which efficiently decide the success rate is an embryo, the number and the quality of the embryo. Most of the failure in the treatment occurs due to false quality embryo used in the treatment. There are techniques like PGD (Pre-implantation diagnosis) which helps the doctor to carry out the most efficient embryo for IVF Treatment. There are embryos that look efficient by outer appearance but are lacking factors needed for pregnancy but on the other hand embryos which don’t look efficient on the outer appearance are most likely to have all the efficiency required for successfully and to determine, differentiate and further select the appropriate embryo the PGD technique is used by the doctors.
Single vs. Multiple embryos
It is recommended that when carrying out IVF treatment only single embryo transfer is considered to be healthy for the pregnancy results. The most important factor for a mother is the health of the baby, so if we transfer multiple embryos the chances of having twins and multiple births increases along with which the risk factor for the baby also increase its level simultaneously. Also, the success rate for both single embryo transfer and multiple embryo transfer is more or less similar. No matter how many numbers of the embryo for IVF are used, one should not neglect the risk factor.
As per one of the studies of “fertility research and practice” it had been calculated that the success rate of “single embryo transfer” was 45% whereas for “Double embryo transfer” was 42%. This clearly shows that it is more likely to be more or less similar to each other. So single embryo, is most likely to be safe and sufficient number of embryos for IVF treatment.