PRP Procedure for IVF and Recurrent Implantation Failure – WHAT IS PRP THERAPY?

PRP Procedure for IVF and Recurrent Implantation Failure – WHAT IS PRP THERAPY?

In recent years, WHAT IS PRP THERAPY? Platelet- Rich Plasma (PRP) has been used alongside conventional fertility treatments like In Vitro Fertilization (IVF) to improve egg quality, uterine lining thickness, and endometrial receptivity, primarily in the treatment of recurrent implantation failure experienced over multiple IVF cycles. While there is not yet a rich source of scientific literture showing it’s overall effectiveness, it is being used more and more frequently due to its clinical success and Can PRP improve AMH? What is ovarian rejuvenation procedure?.

Platelets rich plasma: What is ovarian rejuvenation procedure? Effective embryo implantation requires a proper embryonic development coincident with a receptive endometrium. In clinical practice, satisfactory endometrial growth is needed for successful implantation. The required minimum endometrial thickness for embryo transfer is seven millimeters after the follicular phase. Thin endometrium non-responsive to standard treatments is still a challenge in assisted reproductive technique, which usually results in cycle cancellation and unexpected embryo cryopreservation. Hence various strategies have been developed for treating thin endometrium, including extended use of exogenous estrogen, use of low-dose aspirin, vitamin E and vaginal sildenafil citrate, electroacupuncture and application of granulocyte colony stimulation factor (G-CSF). Can PRP improve AMH? However, several women with thin endometrium remain non-responsive even after these remedies are used. Therefore those patients suffering from weak endometrial growth often ask whether the use of Platelets rich plasma, PRP in IVF can lead to a successful pregnancy. Also can treatment by platelet-rich plasma for endometrial lining will improve it. Alternatively, what is platelet-rich plasma therapy in IVF? Can platelet-rich plasma in repeated IVF failure work effectively? Can you explain PRP fertility treatment? What is PRP therapy in the uterus? Can you explain the use of PRP in IVF? How can PRP lead to IVF success? What is PRP procedure in IVF? Can PRP improve AMH? Does PRP improve egg quality? Does PRP work in recurrent implantation failure? What is the best PRP treatment for male infertility? Can you explain PRP treatment in IVF in Hindi? Is IVF treatment after PRP possible? Are there any PRP fertility success stories you can share? Are there any infertility clinical trials with PRP carried out?

WHAT IS PRP THERAPY?

PRP stands for Platelet-Rich-PlasmaPlasma. PRP is plasma fraction of autologous (own) blood with the concentration of platelets 4-5 times above normal. Platelets are tiny blood cells that are responsible for clotting of blood, growth as well as tissue healing and regeneration

PRP is a concentrated blood product that contains a high percentage of platelets (biomolecules with natural healing and regenerative properties). To understand more, let’s take a step back and look at blood as a whole.  In general, whole blood is composed of 4 main components : What is ovarian rejuvenation procedure?

Plasma: the liquid component of blood that consists mostly of water, dissolved salts and proteins. It constitutes more than half of blood volume and provides the medium for all other components in the blood to be transported throughout the body.

Platelets: Also known as thrombocytes, platelets are cell-like particles that help in the clotting process and release other substances and growth factors.

Red Blood Cells: Also called erythrocytes, red blood cells carry oxygen is involved in the exchange of Oxygen and Carbon Dioxide, brining oxygen to tissue, and removing carbon dioxide from the body.

White Blood Cells: Also known as leukocytes) are white blood cells are primarily responsible for the body’s immune system.

HOW IS PRP THERAPY USED IN INFERTILITY PATIENTS?

PRP Therapy has been recently tried in the following areas: Can PRP improve AMH? and What is ovarian rejuvenation procedure?

  • Persistently Thin Endometrium : Enhances the Endometrial Thickness
  • Addressing Recurrent Implantation Failure (Recurrent Pregnancy Loss)
  • Premature Ovarian Failure : Improves Ovarian Reserve
Process of PRP Therapy for IVF - Recurrent Implantation Failure - Can PRP improve AMH?
Process of PRP Therapy

 HOW IS PRP SAMPLE PREPARED? DO I NEED TO VISIT ANY SPECIAL LAB?

  • Around 10 to 15 ml of blood is drawn from the patient in special tubes. Can PRP improve AMH?
  • Content of the tube is centrifuged (a process of spinning blood at a very high speed to isolate RBC’s, Plasma and Platelets) in a Centrifuge machine.
  • Once the Platelets are isolated in the tube, the separated Platelets along with some leukocytes are transferred to another tube. This is centrifuged again to prepare PRP What is ovarian rejuvenation procedure?.
  • Prepared PRP ( 0.5 to 1 ml ) is then immediately infused into the Endometrial Cavity Can PRP improve AMH?.

HOW IS PRP THERAPY DONE?

0.5 ml to 1 ml of prepared PRP sample is loaded in IUI Catheter and infused in the endometrial cavity. What is ovarian rejuvenation procedure?

The process of transferring the PRP to the Uterus is similar to IUI procedure and done under Ultrasound guidance to increase efficiency. What is ovarian rejuvenation procedure?

Patient may rest for a few minutes and proceed with regular work immediately after the process.

 DO I NEED PRP THERAPY IF I HAVE FAILED MULTIPLE IUI AND IVF CYCLES?

In Recurrent IVF / ICSI Failures, when thin Endometrium is persistently noted or endometrial blood flow is sub-optimal, PRP Therapy should be tried.

Role of PRP in IUI cycles has not been studied.

 IS PRP THERAPY SAFE? ARE THERE ANY SIDE EFFECTS OR DISADVANTAGES OF PRP THERAPY?

PRP sample is prepared from patient’s own blood, hence risk of infection, cross contamination and immunogenic reaction is negligible.

 IS ENDOMETRIAL SCRATCH OR SCRATCHING ALWAYS PERFORMED ALONG WITH PRP THERAPY ?

Endometrial Scratching is a procedure which has been proposed to improve the Receptivity (Ability of Implantation)  of endometrium and thereby increase the Probability of Pregnancy in IVF cycles.

It is usually reserved for patients who have had previous failed IVF ICSI cycles, with good embryos but poor or Thin EndometriumEndometrial Scratch may be combined with PRP to improve chances of pregnancy in IVF or IUI cycles.

Platelet rich plasma PRP preparation steps-Recurrent Implantation Failure-Can PRP improve AMH? What is ovarian rejuvenation procedure?
Platelet rich plasma PRP preparation steps

How is PRP prepared?

PRP is most often used from the person’s blood undergoing the PRP therapy but can be made from another individual’s blood.

Step 1: The PRP process starts with a healthcare professional drawing a sample of blood similar to how they would normally collect tubes of blood.

Step 2: The blood is centrifuged (put in a machine that spins very quickly causing the different components of blood to separate) for about 15 minutes.

Step 3: A lab technician collects the plasma (now rich in platelets and devoid of cellular components) in preparation for its injection.

How is PRP used for IVF and other fertility Treatments?

PRP is used in a number of fertility treatments including IUI and IVF to assist with and improve egg quantity/quality and improve uterine lining thickness/enhance endometrial receptivity during an embryo transfer. It is most often used in those who have undergone multiple IVF cycles with a  history of recurrent implantation failure (RIF), a condition in which multiple IVF transfers do not result in pregnancy despite high-quality embryos being transferred on multiple occasions.  PRP is usually tried before turning to donor egg IVF, but may be used alongside donor egg cycles along with other supporting treatments focusing on reproductive immunology.

PRP for Egg Quantity & Quality-Recurrent Implantation Failure-Can PRP improve AMH? What is ovarian rejuvenation procedure?
PRP for Egg Quantity & Quality-Recurrent Implantation Failure

PRP for Egg Quantity & Quality

PRP may be used to encourage an improvement in egg quality, ovarian rejuvenation, and response to stimulation medications.

There are two ways/procedures in which PRP may be used to improve oocyte quality and quantity:

Intraovarian PRP

This procedure involves injecting 1-3 mls of PRP directly into the ovaries. This procedure is done under monitored anesthesia care by a physician. During the procedure a needle with the PRP is guided via ultrasound through the vaginal wall and into the ovaries where the PRP will then be deposited.

The procedure is ideally done one, two, and or three months PRIOR to the start of an IVF stimulation. It may be done at the time of an egg retrieval, but this would only be beneficial if the person were to undergo another IVF stimulation cycle.

High Volume Intrauterine PRP

During a high volume intrauterine PRP procedure, 8-10 mls are infused slowly into the uterus using an SHG catheter (with a balloon). During the process, the plasma will flow out of the uterus, through the fallopian tubes, and bathe the ovaries in the plasma. After the infusion process is complete, the individual will rest for 10 minutes with the catheter in place.

PRP for Uterine Lining Growth & Endometrial Receptivity (PRP Intrauterine Wash):

PRP may be used to improve the endometrial receptivity of the uterine lining prior to an embryo transfer. This is typically done 48 hours prior to the anticipated embryo transfer. During the procedure, approximately 3-5 mls are infused in the uterus using an IUI catheter. The patient will rests for 10 mins and is subsequently discharged for normal daily activity.  This procedure may be performed by an RN, NP, PA, OBGYN, or reproductive endocrinologist.

If the infusions are intended for lining development (usually for someone with a history of failing to develop an adequate uterine lining) the uterine wash may be performed in a series of procedures. The first PRP infusion would be done at the initial lining check and then repeated 72 hours later if the lining remains inadequate.

Cost of PRP for IVF in Delhi

The cost of PRP varies greatly on when and how it is performed but ranges from $300-1600.

Can Ovarian PRP Treatment help to rejuvenate ovary?

Based on our discussions with top IVF specialist, we can assure that this technology is very promising in the years to come as there are no major side effects observed. But, it’s effectiveness  is still not up to our expectations, considering the fact that it has only handful of success stories.

If you have any further questions on Ovarian PRP treatment and its role in infertility cure or want personalized guidance/counselling on IVF preparation then we are just a call away. We are happy to share that Fertility Dost is having almost 90% success rate to help women and men in improving their health condition in a holistic way. Our team of experts and doctors have specially designed a plan, highly appreciated by our clients, called Fertility Coach Program. We don’t give you medicines but heal you using power of tried and tested ancient techniques.

PRP for Thin Endometrium

By choosing for Platelet Rich Plasma infertility treatments, you can converse some of the reasons of infertility such as untimely menopause subsequent from an injury or illness. Doctors can use PRP to recover your ovaries so patient can grow feasible, healthy follicles, or patch-up the lining of the uterus so that it is supported and can support an IVF implantation.
PRP generates new blood vessels that feed the lining and build fresh connecting tissue. In addition, fertility specialist add hormone additions to support the pregnancy. Thanks to Platelet Rich Plasma for infertility, women were able to bring their babies to full term and have fruitful deliveries.
PRP treatments can work to repair the ovaries so patient can opposing untimely menopause and have healthy babies. To measure you as a suitable patient for Platelet Rich Plasma infertility treatments, your doctor will first confirm that you are otherwise healthy.

Here are some other situations:

  • Patient aged less than 50 years.
  • She reached menopause or are in the peri-menopausal period.
  • She is either more than or below 35 years of age with a low egg standby and levels of the Anti-Mullerian hormones that support in the development of follicles.
  • She has premature ovarian failure.

As use of PRP in infertility treatments is still in the Early stages, it might be answer to many women’s wish to have a healthy baby. A main benefit to using PRP is that it is created from the patient’s own blood.

Use of platelet rich plasma (PRP) in low ovarian reserve

Does PRP help with egg quality?

PRP is used in a number of fertility treatments including IUI and IVF to assist with and improve egg quantity/quality and improve uterine lining thickness/enhance endometrial receptivity during an embryo transfer

Does PRP help implantation?

Recent RCTs of PRP have shown that PRP improves endometrial thickness and increases implantation rates. PRP has also been applied in patients with RIF14 and may represent a potential therapy to optimize the preparation of the endometrium for successful implantation.

Can PRP improve AMH?

PRP treatment resulted in increased antral follicle count (AFC) and serum antimullerian hormone (AMH), while serum follicle stimulating hormone (FSH) did not change significantly.

Does PRP for ovaries work?

Evidence from in vitro studies shows that PRP supports the viability and growth of human early pre-antral follicles (9). Direct injection of PRP into the stroma of poor responder ovaries leads to an increase in the number of follicles and eggs retrieved

Can you get pregnant after PRP?

Our patients achieved pregnancy through natural conception in less than half a year following PRP treatment

What is PRP therapy for uterus?

Intrauterine infusion of platelet-rich plasma (PRP) is a new approach that has been suggested for the treatment of thin endometrium (Chang et al., 2015). PRP is blood plasma prepared from fresh whole blood that has been enriched with platelets.

What is ovarian rejuvenation procedure?

Ovarian rejuvenation is a new procedure that utilizes platelet-rich plasma (PRP) injections to help restore fertility and stimulate natural hormonal production in some women who are unable to conceive or who suffer with symptoms associated with hormone deficiency and Recurrent Implantation Failure.

Can PRP delay menopause?

Besides being used to increase or restart fertility, researchers are looking at ways PRP can be used to counteract the effects of menopause—hot flashes and night sweats and the changes in skin, bones and the heart that happen as women age, by boosting the supply of youthful hormones and delaying menopause symptoms and Recurrent Implantation Failure.

Is thin endometrium curable?

Though plenty of treatment modalities are there to improve the thickness of the uterine wall and the subsequent endometrial receptivity, platelet-rich plasma (PRP) is considered to be the best treatment for endometrial thinning and scarring from miscarriages

How can I increase my endometrial thickness in 2 days naturally?

Exercise is recommended to improve endometrial thickness because it improves blood circulation and increases the blood supply to the womb. At least 30 minutes per day, adjusting your exercise sessions in order not to feel exhausted after a session, are enough

Patient Feedback for PRP – What is ovarian rejuvenation procedure?

“Neha from Delhi, Age 30, also had thin endometrium lining. After 3 failed IVF, she was suggested by her doctor to get PRP treatment. She says,”

“My doctor told me that this treatment have shown good results and so after my retrieval, I went for it. After this PRP treatment, the thickness and quality of my lining improved from 6 to 8.5, but it could not help me further, to make my IVF successful. As far as the procedure is concerned, I did not feel any pain, neither had any side effects nor did I bleed heavily afterwards. This treatment cost me Rs. 8500.”


Komal from Kolkata, Age 36, had low AMH levels. After 1 failed IVF, she was suggested by her doctor to get ovarian PRP treatment. She says,

“My age was 34, when I had my ovarian PRP treatment after 1 failed IVF. Since my AMH levels were low, I went ahead with this treatment. It wasn’t painful, had no side effects, just a little discomfort in lower abdomen for a day. Basically, I did 3 cycles of ovarian PRP treatment  that cost me Rs. 40000 / cycle, it boosted my AMH level from 0.26 to 1.67. Fortunately, 4 eggs were retrieved and later 4 embryos were formed. Initially, l was trying for conceiving naturally, but when that didn’t happen, we went for frozen embryos and conceived with 1 of the embryo. Right now I am 36, and by God’s grace, healthy and 3 months pregnant.”

Bottom Line – Can PRP improve AMH?

Despite a large backing of current scientific literature, PRP is a great treatment to consider alongside your fertility specialist in the treatment of recurrent implantation failure and Can PRP improve AMH?.

As PRP is still considered experimental and at the forefront of fertility treatment innovation, it is not yet offered widely at all fertility clinics. To discuss your options here at CNY Fertility, your first step is scheduling a consultation to speak to one of our fertility specialists.

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